At the time of independence, only three radio stations existed (Lahore, Peshawar, and Dhaka). The first radio station established specifically for the new state in its capital was in Karachi.

Karachi served as the first capital of Pakistan after independence in 1947. In 1960, the capital was shifted to Rawalpindi temporarily and later to the newly built city of Islamabad.

Orient Airways was formed in 1946 and was the first airline in Pakistan. It was later merged with other entities to form the state-owned Pakistan International Airlines (PIA) in 1955.

Hajvery Airline was one of the first private airlines to be granted a license to operate in Pakistan after the deregulation of the aviation sector in the 1990s.

Following the partition, a water dispute arose between India and Pakistan. The first interim agreement regarding canal water usage was signed on May 4, 1948, prior to the eventual Indus Waters Treaty of 1960.

Amir Kror Suri is considered the first known poet of the Pashto language. His work 'Pata Khazana' is often cited as the earliest record of Pashto poetry dating back to the 8th century.

The Karachi Nuclear Power Plant (KANUPP) was Pakistan's first nuclear power facility. It was inaugurated on November 28, 1972, with technical support from Canada.

The first major land reforms in Pakistan were introduced by President Ayub Khan on January 24, 1959. These reforms aimed to reduce land ceiling limits and redistribute land to landless tenants.

Namira Salim (often spelled Numira Saleem) is an explorer and artist who became the first Pakistani to reach the North Pole in April 2007 and the South Pole in January 2008, hoisting the Pakistani flag at both locations.

Nazir Sabir is a renowned Pakistani mountaineer who achieved the historic feat of being the first Pakistani to summit Mount Everest, the world's highest peak, on May 17, 2000.