The verb "grapple" is followed by the preposition "with" when it means to struggle or cope with something.

When Farooq was offered a trip to Hong Kong by his employers he grasped ____ it with both hands.
(a) over (b) on (c) at (d) in

The phrasal verb "give up" means to abandon or surrender something.

The public were warned not to grappled ____ the fugitive, as he was armed and dangerous.
(a) with (b) in (c) on (d) to